Androstenone is the main active ingredient in Servistim.
‘Androstenone is not hard to find. All you have to do is raise your arms. It’s right there in underarm sweat. And depending on your genetic makeup, you may or may not be able to sniff it. Roughly 25 % of the population cannot smell androstenone at all, 40 % think it smells like rotten wood or urine, while the rest find it a pleasing fragrance.
Female animals on the other hand are all sensitive to androstenone. If they are in heat and they smell androstenone, they will immediately assume a mating stance.
That’s because androstenone is a pheromone, in other words, chemical that triggers a social response.
The male produces androstenone and wafts it into the air whenever he is in the mood.
(J Schwarz, The right Chemistry)
Androstenone is a pheromone responsible for the stimulation of sexual responses in the female. Certain neurons in the olfactory bulbs of the female produce excitatory responses to androstenone. Androstenone can either act as a priming pheromone or a signalling pheromone i.e. one that elicits sexual activity. Well known difficulties in heat detection can be minimised through proper stimulation of the reproductive cycle, using androstenone.
Image example of pigs – but applicable to all mammals:
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